Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 19/20 | 0.78 |
| ▸ | DHFR | P00374 | 1/20 | 0.68 |
| ▸ | REN | P00797 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634975 | 0.88 | GHSR (1.00) | GHSRDHFRREN | |
| SCHEMBL3638245 | 0.87 | GHSR (0.77) | GHSRDHFRREN | |
| SCHEMBL3636838 | 0.86 | GHSR (0.83) | GHSRDHFRREN | |
| SCHEMBL3638660 | 0.85 | GHSR (0.92) | GHSRDHFR | |
| SCHEMBL3639519 | 0.82 | GHSR (0.79) | GHSRDHFR | |
| SCHEMBL3633466 | 0.82 | GHSR (0.88) | GHSRDHFRREN | |
| SCHEMBL2669496 | 0.81 | GHSR (1.00) | GHSRDHFR | |
| SCHEMBL3633469 | 0.81 | GHSR (0.84) | GHSRDHFR | |
| SCHEMBL3638931 | 0.80 | GHSR (0.83) | GHSRDHFR | |
| SCHEMBL3638706 | 0.80 | GHSR (0.78) | GHSRDHFRREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | KOSOGOF CHRISTI (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | ABBOTT LABORATORIES | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | GHSR, GIPR, GPR119 | GHSR 1/4885DHFR 465/4885REN 1722/4885 |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | GPR119, GIPR, GCGR | GHSR 5/4885DHFR 534/4885REN 1809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.