Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6341415 | 0.89 | MEN1 (0.44) | MAPTUSP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6343445 | 0.86 | TP53 (0.39) | MAPTSMN1; SMN2PIK3CAMTORTP53 | |
| SCHEMBL6343365 | 0.79 | CCR2 (0.63) | POLB | |
| SCHEMBL6341402 | 0.78 | CYP11B1 (0.41) | MAPTKMT2AMEN1RAB9ACYP11B1 | |
| SCHEMBL6343442 | 0.76 | AOC3 (0.40) | MAPTSMN1; SMN2KMT2AMEN1PIK3CA | |
| SCHEMBL3498780 | 0.76 | MAPT (0.34) | MAPTMCL1KMT2AMEN1POLB | |
| SCHEMBL6339599 | 0.76 | TP53 (0.41) | MAPTSMN1; SMN2KMT2AMEN1PIK3CA | |
| SCHEMBL6341522 | 0.76 | MAPT (0.38) | MAPTUSP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31259518 | 0.73 | MAPT (0.47) | MAPTKMT2AMEN1POLBHTR6 | |
| SCHEMBL5205525 | 0.73 | MCL1 (0.39) | SMN1; SMN2MCL1RAB9ATP53CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |