Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032248 | 0.88 | HSP90B1 (0.44) | CRHR1 | |
| SCHEMBL7028964 | 0.88 | HSP90B1 (0.44) | CRHR1 | |
| SCHEMBL7032141 | 0.87 | HSP90B1 (0.45) | CRHR1 | |
| SCHEMBL7237191 | 0.81 | ERBB2 (0.40) | CRHR1 | |
| SCHEMBL7036754 | 0.81 | ERBB2 (0.42) | CRHR1 | |
| SCHEMBL7036738 | 0.80 | ERBB2 (0.43) | CRHR1 | |
| SCHEMBL7033696 | 0.79 | ERBB2 (0.42) | — | |
| SCHEMBL6355664 | 0.79 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL7029124 | 0.76 | ERBB2 (0.55) | CRHR1 | |
| SCHEMBL7033056 | 0.76 | ERBB2 (0.55) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974808-B2 | CRF receptor antagonists and methods relating thereto | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20020049207-A1 | CRF receptor antagonists and methods relating thereto | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-25 | — | — | US | disclosed |
| US-6352990-B1 | A METHOD OF TREATING ANXIETY AND DEPRESSION IN A WARM-BLOODED ANIMAL AND TREATMENT OF STROKES | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049207-A1 | CRF receptor antagonists and methods relating thereto | CRHR1, CRH, CRHR2 | CRHR1 1/4885CNR1 25/4885KCNH2 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.