SCHEMBL6356578

SCHEMBL6356578

Cc1nc2ccccc2c(=O)n1CCOc1ccc(CC2SC(=O)NC2=O)cc1.[Na]

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 10/20 0.68
FFAR1 O14842 10/20 0.59
PPARA Q07869 5/20 0.55
HRH3 Q9Y5N1 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5935692 0.99 PPARG (0.69) PPARGFFAR1PPARAHRH3
SCHEMBL6356577 0.98 PPARG (0.68) PPARGFFAR1PPARAHRH3
SCHEMBL5935653 0.90 PPARG (0.57) PPARGFFAR1PPARA
Hydrochloric Acid SCHEMBL6856665 0.89 PPARG (0.56) PPARGFFAR1PPARA
SCHEMBL6358469 0.89 PPARG (0.71) PPARGFFAR1PPARA
SCHEMBL5935594 0.88 PPARG (0.73) PPARGFFAR1PPARA
SCHEMBL6358465 0.87 PPARG (0.71) PPARGFFAR1PPARA
Balaglitazone SCHEMBL5935616 0.82 PPARG (0.98) PPARGFFAR1PPARA
SCHEMBL5844579 0.81 PPARG (0.80) PPARGFFAR1PPARA
Balaglitazone SCHEMBL20125575 0.81 PPARG (1.00) PPARGFFAR1PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050032864-A1 Novel heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases DR. REDDY'S LABORATORIES LIMITED 2005-02-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050032864-A1 Novel heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases IAPP, GPR119, CYP11B2 PPARG 380/4885FFAR1 1350/4885PPARA 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.