Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | SDCBP | O00560 | 1/20 | 0.35 |
| ▸ | SDC2 | P34741 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6349228 | 0.94 | MEN1 (0.39) | MEN1KMT2AMAPTMMESDCBP | |
| SCHEMBL6349375 | 0.89 | LTA4H (0.37) | MMELTA4HPYGLLMNATDP1 | |
| SCHEMBL6347591 | 0.83 | MME (0.40) | MEN1KMT2AMAPTMMEACE | |
| SCHEMBL6347587 | 0.83 | MME (0.40) | MEN1KMT2AMAPTMMEACE | |
| SCHEMBL6352185 | 0.82 | BACE1 (0.37) | MMELTA4HPYGLLMNA | |
| SCHEMBL6356999 | 0.80 | MAPT (0.46) | MEN1KMT2AMAPTLMNATDP1 | |
| SCHEMBL6357003 | 0.80 | MAPT (0.46) | MEN1KMT2AMAPTLMNATDP1 | |
| SCHEMBL6347832 | 0.77 | MME (0.33) | MEN1KMT2AMAPTMME | |
| SCHEMBL6347829 | 0.77 | MME (0.33) | MEN1KMT2AMAPTMME | |
| SCHEMBL6348128 | 0.77 | MEN1 (0.39) | MEN1KMT2AMAPTMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |