Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6348251 | 0.88 | PYGL (0.37) | BACE1BCHELMNAPYGLPOLB | |
| SCHEMBL6359323 | 0.87 | SMN1; SMN2 (0.37) | BACE1BCHELMNAPYGLPOLB | |
| SCHEMBL6348190 | 0.86 | PYGL (0.36) | BACE1BCHELMNAPYGLPOLB | |
| SCHEMBL6358303 | 0.84 | HDAC3 (0.35) | BACE1LMNAPYGLPOLBALDH1A1 | |
| SCHEMBL6349228 | 0.84 | MEN1 (0.39) | LMNAPYGLPOLBALDH1A1MME | |
| SCHEMBL6346933 | 0.83 | ALDH1A1 (0.40) | LMNAPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL6349375 | 0.83 | LTA4H (0.37) | LMNAPYGLNPC1RAB9AMME | |
| SCHEMBL6356592 | 0.82 | MEN1 (0.35) | LMNAPYGLMMELTA4H | |
| SCHEMBL6348393 | 0.80 | POLB (0.38) | BACE1BCHELMNAPYGLPOLB | |
| SCHEMBL6354395 | 0.80 | POLB (0.38) | BACE1BCHELMNAPYGLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |