Efegatran

Efegatran

SCHEMBL635674

CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCNC(=N)N

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F2 P00734 4/20 0.58
PLG P00747 2/20 0.58
PRSS1 P07477 2/20 0.48
XIAP P98170 4/20 0.48
OPRM1 P35372 6/20 0.47
OPRK1 P41145 6/20 0.47
F10 P00742 1/20 0.45
EPHA2 P29317 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Efegatran SCHEMBL7273879 0.97 F2 (0.56) F2PLGPRSS1XIAPOPRM1
Efegatran SCHEMBL7264662 0.97 F2 (0.56) F2PLGPRSS1XIAPOPRM1
Efegatran SCHEMBL564291 0.97 F2 (0.56) F2PLGPRSS1XIAPOPRM1
Efegatran SCHEMBL7412481 0.97 F2 (0.56) F2PLGPRSS1XIAPOPRM1
Efegatran SCHEMBL1229047 0.96 F2 (0.55) F2PLGPRSS1XIAPOPRM1
Hydrochloric Acid SCHEMBL7296655 0.93 F2 (0.59) F2PLGPRSS1XIAPOPRM1
Hydrochloric Acid SCHEMBL7409436 0.92 F2 (0.59) F2PLGPRSS1XIAPOPRM1
SCHEMBL7448422 0.91 F2 (0.58) F2PLGPRSS1
SCHEMBL7446078 0.91 F2 (0.56) F2PLGPRSS1XIAPOPRM1
Acetic Acid SCHEMBL10728075 0.90 F2 (0.56) F2PLGOPRM1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1098 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12521258-B2 Anticoagulant compounds and methods and devices for their use ELIXIR MEDICAL CORPORATION (US) 2026-01-13 US claimed
WO-2025262269-A1 MONITORING OF REVERSAL AGENTS FOR ANTICOAGULANTS ENZYRE B.V. (NL) 2025-12-26 WO claimed
US-20240424175-A1 ANTICOAGULANT COMPOUNDS COMPRISING CHELATING AGENTS AND CATIONIC ANTI-COAGULATION ENHANCERS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2024-12-26 US claimed
WO-2024238703-A1 ANTICOAGULANT COMPOSITIONS COMPRISING ANTI-PLATELET AND ANTI-INFLAMMATORY DRUGS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2024-11-21 WO claimed
US-20240189495-A1 METHODS OF PREPARING AN EXTRACORPOREAL CIRCUIT FOR ANTICOAGULATION LOWELL THERAPEUTICS, LLC 2024-06-13 US claimed
EP-4326363-A1 METHODS OF PREPARING AN EXTRACORPOREAL CIRCUIT FOR ANTICOAGULATION Lowell Therapeutics, LLC (US) 2024-02-28 EP claimed
US-20230293540-A1 ANTICOAGULANT COMPOUNDS, METHODS AND DEVICES FOR OPHTHALMIC USE ELIXIR MEDICAL CORPORATION (US) 2023-09-21 US claimed
US-20230190499-A1 ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2023-06-22 US claimed
US-20230165874-A1 ANTICOAGULANT COMPOUNDS AND METHODS AND DEVICES FOR THEIR PULMONARY USE ELIXIR MEDICAL CORPORATION (US) 2023-06-01 US claimed
WO-2023096800-A1 ANTICOAGULANT COMPOUNDS COMPRISING CHELATING AGENTS AND CATIONIC ANTI-COAGULATION ENHANCERS AND METHODS AND DEVICES FOR THEIR USE ELIXIR MEDICAL CORPORATION (US) 2023-06-01 WO claimed
US-20020009753-A1 Anticoagulant test BEDNAR BOHUMIL (US) 2002-01-24 US claimed
US-20010036913-A1 Combination therapy for reducing the risks associated with cardiovascular disease GOULD ROBERT J (US) 2001-11-01 US claimed
US-6235706-B1 Combination therapy for reducing the risks associated with cardiovascular disease MERCK & CO., INC. 2001-05-22 US claimed
US-6210904-B1 DIAGNOSING FOR RISK OF THROMOCYTOPENIA BY DETECTING ABSENCE OF ASSOCIATION OF MONOCLONAL ANTIBODY WITH GLYCOPROTEIN IIB/IIA RECEPTOR:GLYCOPROTEIN IIB/IIA RECEPTOR ANTAGONIST COMPLEX MERCK & CO., INC. 2001-04-03 US claimed
US-6136804-A ANTIISCHEMIC AGENTS, ANTITHROMBOTIC AGENTS, THROMBOTIC OCCLUSION AND ANTIPLATELET AGENT MERCK & CO., INC. (US) 2000-10-24 US claimed
US-6063584-A Anticoagulant test MERCK & CO., INC. (US) 2000-05-16 US claimed
US-5978698-A Angioplasty procedure using nonionic contrast media MERCK & CO., INC. (US) 1999-11-02 US claimed
WO-1997035579-A1 A METHOD FOR INHIBITING CLOT FORMATION MERCK & CO., INC. (US) 1997-10-02 WO claimed
US-5455229-A A tripeptide based on a alanine, proline and arginine derivative; protease inhibitors; myocardial infarctions ELI LILLY AND COMPANY (US) 1995-10-03 US claimed
EP-0606003-A1 Method for minimizing and containing ischemic and reperfusion injury ELI LILLY AND COMPANY (US) 1994-07-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010036913-A1 Combination therapy for reducing the risks associated with cardiovascular disease HMGCR, PCSK9, APOB F2 37/4885PLG 130/4885PRSS1 1039/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.