Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253371 | 0.89 | PTGS1 (0.68) | PTGS2PTGS1IKBKBCCNA2CDK2 | |
| SCHEMBL5256651 | 0.89 | PTGS2 (0.68) | PTGS2PTGS1IKBKBCCNA2CDK2 | |
| SCHEMBL8471667 | 0.80 | PTGS2 (0.66) | PTGS2PTGS1IKBKBCCNA2CDK2 | |
| SCHEMBL6279437 | 0.78 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL9832871 | 0.76 | PTGS1 (0.49) | PTGS2PTGS1MAPTCCNA2CDK2 | |
| SCHEMBL6352140 | 0.74 | RAD52 (0.56) | PTGS2PTGS1IKBKBCCNA2CDK2 | |
| SCHEMBL9833010 | 0.74 | PTGS1 (0.47) | PTGS2PTGS1MAPTCCNA2CDK2 | |
| SCHEMBL6649029 | 0.73 | PTGS1 (0.48) | PTGS2PTGS1MAPTIKBKBCCNA2 | |
| Hydrochloric Acid SCHEMBL6800512 | 0.73 | PTGS2 (0.51) | PTGS2PTGS1IKBKBCCNA2CDK2 | |
| SCHEMBL9834202 | 0.73 | PIK3CD (0.45) | PTGS2PTGS1MAPTCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050100594-A1 | Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2005-05-12 | — | — | US | disclosed |
| US-5886016-A | ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5670532-A | Pyrazolyl derivatives for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5565482-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5547975-A | ANTIARTHRIC AGENTS, ANALGESICS AND ANTIPYRETICS; INHIBITORS OF CYCLOOXYGENASE II; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 1996-08-20 | — | — | US | disclosed |