Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 17/20 | 0.45 |
| ▸ | CDK2 | P24941 | 17/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 17/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253371 | 0.84 | PTGS1 (0.68) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL9832871 | 0.77 | PTGS1 (0.49) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL5256651 | 0.76 | PTGS2 (0.68) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL9833010 | 0.75 | PTGS1 (0.47) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL14502642 | 0.75 | CCNA2 (0.53) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL2548370 | 0.75 | MAPT (0.62) | CCNA2CDK2CCNA1MAPTPOLB | |
| SCHEMBL6681492 | 0.74 | CCNA2 (0.49) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL14532800 | 0.74 | CCNA2 (0.52) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL6356759 | 0.73 | PTGS2 (0.64) | PTGS1PTGS2CCNA2CDK2CCNA1 | |
| SCHEMBL9831849 | 0.73 | PTGS1 (0.42) | PTGS1PTGS2CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427706-A1 | SUBSTITUTED PYRAZOLO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-06-16 | — | — | EP | claimed |
| WO-2003024936-A1 | SUBSTITUTED PYRAZOLO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | claimed |