Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 2/20 | 0.40 |
| ▸ | PYGM | P11217 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6356948 | 0.81 | MEN1 (0.47) | CTSSOPRM1OPRK1OPRL1CHRNA7 | |
| SCHEMBL8311914 | 0.75 | KMT2A (0.39) | TAS1R3TAS1R1TAS1R2PYGLPYGM | |
| SCHEMBL7101763 | 0.75 | KDM4E (0.48) | CTSS | |
| SCHEMBL8307649 | 0.70 | CHRM4 (0.49) | — | |
| SCHEMBL6363447 | 0.67 | KMT2A (0.43) | TAS1R3TAS1R1TAS1R2PYGLPYGM | |
| SCHEMBL6811167 | 0.66 | CHRM4 (0.50) | — | |
| SCHEMBL8312441 | 0.65 | CHRM4 (0.47) | — | |
| SCHEMBL5969864 | 0.64 | CA12 (0.56) | PDE4APDE4BPDE4CPDE4DTSHR | |
| Hydrochloric Acid SCHEMBL7929443 | 0.63 | CA12 (0.54) | TSHR | |
| SCHEMBL27517416 | 0.63 | HPGD (0.54) | TAS1R3TAS1R2POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874625-B1 | INDANE DERIVATIVES FOR ANTIPSYCHOTIC COMPOSITIONS | LILLY CO ELI (US) | 2005-03-16 | — | — | EP | disclosed |
| US-6429317-B1 | MUSCARINIC RECEPTOR MODULATORS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; SCHIZOPHRENIA | ELI LILLY AND COMPANY | 2002-08-06 | — | — | US | disclosed |
| US-6395735-B2 | AN INDANE-LIKE COMPOUNDS WHICH CAN BE USEFUL FOR TREATING PSYCHOSIS AND OTHER CONDITIONS ASSOCIATED WITH MODULATION OF A MUSCARINIC RECEPTOR | ELI LILLY AND COMPANY | 2002-05-28 | — | — | US | disclosed |
| US-20010012848-A1 | Pharmaceutical compounds | HOLLINSHEAD SEAN PATRICK (US) | 2001-08-09 | — | — | US | disclosed |
| US-6211364-B1 | PSYCHOLOGICAL DISORDERS; ALZHEIMER'S DISEASE; CROHN'S DISEASE; PARKINSON DISEASES | ELI LILLY AND COMPANY | 2001-04-03 | — | — | US | disclosed |
| EP-0971885-A4 | PROCESS FOR PREPARING INDANE-LIKE COMPOUNDS | LILLY CO ELI (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-0971885-A1 | PROCESS FOR PREPARING INDANE-LIKE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998031660-A1 | PROCESS FOR PREPARING INDANE-LIKE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1998-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010012848-A1 | Pharmaceutical compounds | CHRM5, CHRM4, CHRM3 | TAS1R3 567/4885TAS1R1 539/4885TAS1R2 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.