Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358677 | 0.85 | ALDH1A1 (0.35) | ALDH1A1SLC6A3BRD4HTR3EHTR3B | |
| SCHEMBL6357052 | 0.77 | ALDH1A1 (0.36) | ALDH1A1BRD4 | |
| SCHEMBL6357295 | 0.77 | ALDH1A1 (0.32) | ALDH1A1BRD4 | |
| SCHEMBL5402088 | 0.71 | CYP1A2 (0.38) | ALDH1A1SLC6A3BRD4 | |
| SCHEMBL5412750 | 0.71 | CYP1A2 (0.43) | ALDH1A1SLC6A3BRD4 | |
| SCHEMBL5622288 | 0.71 | CYP1A2 (0.38) | ALDH1A1SLC6A3BRD4 | |
| SCHEMBL5401654 | 0.71 | CYP1A2 (0.38) | ALDH1A1SLC6A3BRD4 | |
| SCHEMBL5416984 | 0.71 | CYP1A2 (0.43) | ALDH1A1SLC6A3BRD4 | |
| SCHEMBL5412755 | 0.71 | CYP1A2 (0.43) | ALDH1A1SLC6A3BRD4 | |
| SCHEMBL5407607 | 0.71 | CYP1A2 (0.38) | ALDH1A1SLC6A3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996619-B1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX INC (US) | 2005-01-05 | — | — | EP | claimed |
| EP-0996619-B1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX INC (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-1493744-A1 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2005-01-05 | — | — | EP | disclosed |
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | disclosed |
| US-6353105-B1 | INHIBITORS OF 5-HYDROXY-TRYPTAMINE REUPTAKE OF A MONOAMINE TRANSPORTER; ANALOGS OF COCAINE; | ORGANIX, INC. | 2002-03-05 | — | — | US | disclosed |
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | ALDH1A1 614/4885SLC6A3 3/4885BRD4 4271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.