Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358479 | 0.80 | HCRTR1 (0.56) | TDP1HTTNPSR1HCRTR1HCRTR2 | |
| SCHEMBL6363450 | 0.78 | ALDH1A1 (0.43) | TDP1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6356899 | 0.77 | ALDH1A1 (0.39) | TDP1MEN1KMT2ASMN1; SMN2HTR2A | |
| SCHEMBL17502633 | 0.67 | NPSR1 (0.76) | TDP1HTTNPSR1TSHRMEN1 | |
| SCHEMBL11715064 | 0.67 | NPSR1 (0.81) | TDP1HTTNPSR1TSHRMEN1 | |
| SCHEMBL18051872 | 0.66 | NPSR1 (0.74) | TDP1HTTNPSR1TSHRMEN1 | |
| SCHEMBL17946045 | 0.63 | NPSR1 (0.67) | TDP1HTTNPSR1HCRTR1HCRTR2 | |
| SCHEMBL11907811 | 0.62 | HCRTR1 (0.61) | HTTHCRTR1HCRTR2 | |
| SCHEMBL9857776 | 0.62 | NPSR1 (0.71) | TDP1HTTNPSR1HCRTR1HCRTR2 | |
| SCHEMBL1520673 | 0.62 | NPSR1 (1.00) | TDP1HTTNPSR1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234090-A1 | Modulators of chemokine receptor activity | PFIZER INC | 2005-10-20 | — | — | US | disclosed |
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |
| EP-1368354-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| US-20030008893-A1 | Modulators of chemokine receptor activity | COLON-CRUZ ROBERTO (US) | 2003-01-09 | — | — | US | disclosed |
| WO-2002070523-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008893-A1 | Modulators of chemokine receptor activity | CCR1, CCR3, CCR2 | TDP1 3700/4885HTT 4481/4885NPSR1 282/4885 |
| US-20050234090-A1 | Modulators of chemokine receptor activity | CCR3, CCR2, CCR1 | TDP1 3782/4885HTT 4503/4885NPSR1 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.