Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350685 | 1.00 | KMT2A (0.38) | KMT2ANPC1MEN1TRPM8AGTR1 | |
| SCHEMBL6347935 | 0.90 | KMT2A (0.39) | KMT2ANPC1MEN1AGTR1POLB | |
| SCHEMBL6359182 | 0.90 | KMT2A (0.39) | KMT2ANPC1MEN1AGTR1POLB | |
| SCHEMBL6350601 | 0.84 | KMT2A (0.42) | KMT2ANPC1MEN1TRPM8AGTR1 | |
| SCHEMBL6354208 | 0.82 | ALDH1A1 (0.43) | KMT2ANPC1MEN1TRPM8AGTR1 | |
| SCHEMBL6350864 | 0.82 | TRPM8 (0.47) | KMT2AMEN1TRPM8AGTR1KDM4E | |
| SCHEMBL6347733 | 0.82 | ALDH1A1 (0.43) | KMT2ANPC1MEN1TRPM8AGTR1 | |
| SCHEMBL6359179 | 0.82 | TRPM8 (0.47) | KMT2AMEN1TRPM8AGTR1KDM4E | |
| SCHEMBL6347856 | 0.82 | ALDH1A1 (0.43) | KMT2ANPC1MEN1TRPM8AGTR1 | |
| SCHEMBL6357950 | 0.82 | ALDH1A1 (0.48) | KMT2ANPC1MEN1TRPM8AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |
| EP-1211249-A1 | NOVEL THIAZINE OR PYRAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-05 | — | — | EP | disclosed |