Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 4/20 | 0.64 |
| ▸ | NSD2 | O96028 | 5/20 | 0.59 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.59 |
| ▸ | SETD7 | Q8WTS6 | 4/20 | 0.59 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.59 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.59 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.58 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.58 |
| ▸ | NNMT | P40261 | 3/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.58 |
| ▸ | TRDMT1 | O14717 | 2/20 | 0.58 |
| ▸ | INMT | O95050 | 2/20 | 0.58 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.58 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.58 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.58 |
| ▸ | PRMT7 | Q9NVM4 | 2/20 | 0.58 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.58 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.58 |
| ▸ | PNMT | P11086 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28733072 | 1.00 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 | |
| Succinic Acid SCHEMBL31363215 | 1.00 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL215732 | 0.97 | MARS1 (0.68) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL21053165 | 0.97 | MARS1 (0.68) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL29352263 | 0.97 | MARS1 (0.68) | MARS1NSD2CARM1SETD7PRMT1 | |
| Racemethionine SCHEMBL25262839 | 0.96 | MARS1 (0.66) | MARS1NSD2CARM1SETD7PRMT1 | |
| Hydrogen Sulfide SCHEMBL28823955 | 0.96 | MARS1 (0.67) | MARS1NSD2CARM1SETD7PRMT1 | |
| Bicarbonate SCHEMBL18351663 | 0.96 | MARS1 (0.67) | MARS1NSD2CARM1SETD7PRMT1 | |
| Sulfuric Acid SCHEMBL636869 | 0.93 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 | |
| Sulfuric Acid SCHEMBL5613159 | 0.93 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2071022-B1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | BIORIGHT WORLDWIDE CO LTD (VG) | 2012-02-22 | — | — | EP | claimed |
| US-7858351-B2 | S-adenosylmethionine synthetase mutants, the DNAs encoding the same and uses of the mutants | GENEHARBOR ( HONG KONG) TECHNOLOGIES, LTD. (CN) | 2010-12-28 | — | — | US | claimed |
| US-20090203080-A1 | S-Adenosylmethionine Synthetase Mutants, the DNAs Encoding the Same and Uses of the Mutants | GENEHARBOR (HONG KONG) TECHNOLOGIES LTD. (CN) | 2009-08-13 | — | — | US | claimed |
| EP-2071022-A1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | Bioright Worldwide Company Limited (VG) | 2009-06-17 | — | — | EP | claimed |
| EP-2071022-B1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | BIORIGHT WORLDWIDE CO LTD (VG) | 2012-02-22 | — | — | EP | disclosed |
| US-7858351-B2 | S-adenosylmethionine synthetase mutants, the DNAs encoding the same and uses of the mutants | GENEHARBOR ( HONG KONG) TECHNOLOGIES, LTD. (CN) | 2010-12-28 | — | — | US | disclosed |
| US-20090203080-A1 | S-Adenosylmethionine Synthetase Mutants, the DNAs Encoding the Same and Uses of the Mutants | GENEHARBOR (HONG KONG) TECHNOLOGIES LTD. (CN) | 2009-08-13 | — | — | US | disclosed |
| EP-2071022-A1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | Bioright Worldwide Company Limited (VG) | 2009-06-17 | — | — | EP | disclosed |