Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 4/20 | 0.64 |
| ▸ | NSD2 | O96028 | 7/20 | 0.61 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.61 |
| ▸ | SETD7 | Q8WTS6 | 4/20 | 0.61 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.61 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.61 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.58 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.58 |
| ▸ | FASN | P49327 | 2/20 | 0.58 |
| ▸ | TRDMT1 | O14717 | 2/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.58 |
| ▸ | INMT | O95050 | 2/20 | 0.58 |
| ▸ | NNMT | P40261 | 2/20 | 0.58 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.58 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.58 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.58 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.58 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.58 |
| ▸ | PNMT | P11086 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL27680964 | 1.00 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 | |
| Sulfuric Acid SCHEMBL5613159 | 1.00 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL21053165 | 0.97 | MARS1 (0.68) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL215732 | 0.97 | MARS1 (0.68) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL29352263 | 0.97 | MARS1 (0.68) | MARS1NSD2CARM1SETD7PRMT1 | |
| Bicarbonate SCHEMBL18351663 | 0.96 | MARS1 (0.67) | MARS1NSD2CARM1SETD7PRMT1 | |
| Hydrogen Sulfide SCHEMBL28823955 | 0.96 | MARS1 (0.67) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL25243681 | 0.95 | MARS1 (0.60) | MARS1NSD2CARM1SETD7PRMT1 | |
| SCHEMBL29553380 | 0.95 | MARS1 (0.60) | MARS1NSD2CARM1SETD7PRMT1 | |
| Succinic Acid SCHEMBL636286 | 0.93 | MARS1 (0.64) | MARS1NSD2CARM1SETD7PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2071022-B1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | BIORIGHT WORLDWIDE CO LTD (VG) | 2012-02-22 | — | — | EP | claimed |
| US-7858351-B2 | S-adenosylmethionine synthetase mutants, the DNAs encoding the same and uses of the mutants | GENEHARBOR ( HONG KONG) TECHNOLOGIES, LTD. (CN) | 2010-12-28 | — | — | US | claimed |
| US-20090203080-A1 | S-Adenosylmethionine Synthetase Mutants, the DNAs Encoding the Same and Uses of the Mutants | GENEHARBOR (HONG KONG) TECHNOLOGIES LTD. (CN) | 2009-08-13 | — | — | US | claimed |
| EP-2071022-A1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | Bioright Worldwide Company Limited (VG) | 2009-06-17 | — | — | EP | claimed |
| EP-3071191-A1 | SLOW-RELEASE SOLID ORAL COMPOSITIONS | Gnosis S.p.A. (IT) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015071806-A1 | SLOW-RELEASE SOLID ORAL COMPOSITIONS | GNOSIS SPA (IT) | 2015-05-21 | — | — | WO | disclosed |
| EP-2071022-B1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | BIORIGHT WORLDWIDE CO LTD (VG) | 2012-02-22 | — | — | EP | disclosed |
| US-7858351-B2 | S-adenosylmethionine synthetase mutants, the DNAs encoding the same and uses of the mutants | GENEHARBOR ( HONG KONG) TECHNOLOGIES, LTD. (CN) | 2010-12-28 | — | — | US | disclosed |
| US-20090203080-A1 | S-Adenosylmethionine Synthetase Mutants, the DNAs Encoding the Same and Uses of the Mutants | GENEHARBOR (HONG KONG) TECHNOLOGIES LTD. (CN) | 2009-08-13 | — | — | US | disclosed |
| EP-2071022-A1 | S-ADENOSYLMETHIONINE SYNTHETASE MUTANTS, THE DNAS ENCODING THE SAME AND USES OF THE MUTANTS | Bioright Worldwide Company Limited (VG) | 2009-06-17 | — | — | EP | disclosed |