Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366217 | 0.91 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL3996666 | 0.90 | ALDH1A1 (0.53) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL1607919 | 0.81 | TRIM24 (0.52) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL11337902 | 0.79 | TRIM24 (0.50) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL708367 | 0.79 | ALDH1A1 (0.55) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL28897127 | 0.78 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL9750772 | 0.78 | TRIM24 (0.48) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL10852053 | 0.77 | TRIM24 (0.47) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL9225514 | 0.77 | TRIM24 (0.55) | ALDH1A1NPC1RAB9ATRIM24TRIM33 | |
| SCHEMBL6015786 | 0.76 | TRIM24 (0.46) | ALDH1A1NPC1RAB9ATRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250836-A1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250836-A1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | WEE1, WEE2, CHEK1 | ALDH1A1 2805/4885NPC1 4059/4885RAB9A 2939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.