Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 19/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6371220 | 0.91 | ADRA1A (0.83) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| Fumaric Acid SCHEMBL6371209 | 0.91 | ADRA1A (0.83) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| SCHEMBL6371845 | 0.86 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| SCHEMBL6368060 | 0.81 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| SCHEMBL6367331 | 0.79 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| SCHEMBL6367665 | 0.79 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| Fumaric Acid SCHEMBL6366510 | 0.78 | ADRA1A (0.82) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| Fumaric Acid SCHEMBL6366505 | 0.78 | ADRA1A (0.82) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| SCHEMBL6368282 | 0.77 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2BADRA2C | |
| SCHEMBL6366434 | 0.76 | ADRA2B (0.79) | ADRA1AADRA1DADRA1BADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | claimed |
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |