Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.94 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.94 |
| ▸ | ADRA1D | P25100 | 14/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366831 | 0.97 | ADRA1A (1.00) | ADRA1AADRA1BADRA1D | |
| Hydrochloric Acid SCHEMBL6367046 | 0.96 | ADRA1A (0.98) | ADRA1AADRA1BADRA1D | |
| SCHEMBL6367171 | 0.92 | ADRA1A (1.00) | ADRA1AADRA1BADRA1D | |
| Hydrochloric Acid SCHEMBL6367642 | 0.91 | ADRA1A (0.98) | ADRA1AADRA1BADRA1D | |
| SCHEMBL6367306 | 0.87 | ADRA1A (1.00) | ADRA1AADRA1BADRA1D | |
| SCHEMBL6365559 | 0.84 | ADRA1A (0.74) | ADRA1AADRA1BADRA1D | |
| SCHEMBL6367193 | 0.83 | ADRA1A (0.76) | ADRA1AADRA1BADRA1D | |
| SCHEMBL6371044 | 0.82 | ADRA1A (1.00) | ADRA1AADRA1BADRA1D | |
| Hydrochloric Acid SCHEMBL6367748 | 0.82 | ADRA1A (0.74) | ADRA1AADRA1BADRA1D | |
| SCHEMBL7529066 | 0.82 | ADRA1A (0.79) | ADRA1AADRA1BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |