Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.76 |
| ▸ | ADRA1D | P25100 | 17/20 | 0.76 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6367748 | 0.99 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BADRA2AADRA2C | |
| SCHEMBL6366831 | 0.86 | ADRA1A (1.00) | ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL6367046 | 0.85 | ADRA1A (0.98) | ADRA1AADRA1DADRA1BADRA2C | |
| SCHEMBL6366626 | 0.83 | ADRA1A (0.94) | ADRA1AADRA1DADRA1B | |
| SCHEMBL6366856 | 0.82 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL7632791 | 0.80 | ADRA1A (0.53) | ADRA1AADRA1DADRA1BADRA2AADRA2C | |
| SCHEMBL6367171 | 0.79 | ADRA1A (1.00) | ADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL6367642 | 0.78 | ADRA1A (0.98) | ADRA1AADRA1DADRA1BADRA2C | |
| SCHEMBL6367306 | 0.74 | ADRA1A (1.00) | ADRA1AADRA1DADRA1B | |
| Propane SCHEMBL6367133 | 0.73 | ADRA1A (0.66) | ADRA1AADRA1DADRA1BADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |