Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | GLA | P06280 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | HBB | P68871 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 2/20 | 0.72 |
| ▸ | STAT6 | P42226 | 1/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | GMNN | O75496 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649174 | 0.89 | TOP1 (0.69) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27540723 | 0.89 | TOP1 (0.77) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27547279 | 0.89 | TOP1 (0.76) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6232779 | 0.89 | TOP1 (0.77) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8486195 | 0.89 | TOP1 (0.76) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8324984 | 0.89 | TOP1 (0.78) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7627096 | 0.88 | TOP1 (0.75) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7263268 | 0.88 | TOP1 (0.75) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7677097 | 0.88 | TOP1 (0.77) | TOP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7262301 | 0.88 | TOP1 (0.65) | TOP1ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963988-B1 | Intermediates for making camptothecin and camptothecin analogs | UNIV NORTH CAROLINA STATE (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-0646117-B1 | METHODS AND INTERMEDIATES FOR THE ASYMMETRIC SYNTHESIS OF CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | UNIV NORTH CAROLINA STATE (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1020468-A2 | Methods and intermediates for the asymmetric synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 2000-07-19 | — | — | EP | disclosed |
| EP-0565621-B1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | UNIV NORTH CAROLINA STATE (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-0963988-A2 | Method of making camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5478943-A | Method of making intermediates for camptothecin and its analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5475108-A | Camptothecin intermediates and method of making camptothecin and comptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0646117-A1 | METHODS AND INTERMEDIATES FOR THE ASYMMETRIC SYNTHESIS OF CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5321140-A | Pyridinecarboxaldehyde D-ring intermediates useful for the synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1994-06-14 | — | — | US | disclosed |
| US-5315007-A | Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1994-05-24 | — | — | US | disclosed |
| US-5258516-A | Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs | NC STATE UNIVERSITY (US) | 1993-11-02 | — | — | US | disclosed |
| EP-0565621-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5254690-A | Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5247089-A | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5243050-A | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-07 | — | — | US | disclosed |
| US-5212317-A | Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-05-18 | — | — | US | disclosed |
| US-5200524-A | Camptothecin intermediates and method of making same | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-04-06 | — | — | US | disclosed |
| US-5191082-A | Camptothecin intermediate and method of making camptothecin intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-03-02 | — | — | US | disclosed |
| US-5162532-A | INTERMEDIATES AND METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-11-10 | — | — | US | disclosed |
| WO-1992011263-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-07-09 | — | — | WO | disclosed |