Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | PPARD | Q03181 | 6/20 | 0.52 |
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900636 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL7748806 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL6901628 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL6900744 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL6899202 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL6902041 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL6901617 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL9661395 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL21357404 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL2275936 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852686-B2 | Methods for ameliorating icthyosiform skin diseases | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-02-08 | — | — | US | disclosed |
| US-20030072795-A1 | Methods for ameliorating icthyosiform skin diseases | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE | 2003-04-17 | — | — | US | disclosed |
| WO-2000078937-A1 | METHODS FOR AMELIORATING ICTHYOSIFORM SKIN DISEASES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2000-12-28 | — | — | WO | disclosed |