Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | C1R | P00736 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122030 | 0.87 | TDP1 (0.51) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL14600789 | 0.81 | MAPT (0.55) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10552846 | 0.81 | MAPT (0.55) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL13232017 | 0.77 | MAPT (0.52) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL8825191 | 0.76 | MAPT (0.48) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL5959914 | 0.76 | NPC1 (0.63) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6367677 | 0.75 | MAPT (0.52) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL8362955 | 0.74 | NPC1 (0.58) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL11477671 | 0.74 | RAB9A (0.61) | MAPTKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL14600784 | 0.74 | NPC1 (0.53) | MAPTKMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | MAPT 3694/4885KMT2A 441/4885NPC1 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.