Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112426 | 0.87 | TDP1 (0.51) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL20225769 | 0.83 | S1PR1 (0.48) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL10553914 | 0.81 | MAPT (0.49) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL11477671 | 0.80 | RAB9A (0.61) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL2213043 | 0.78 | MAPT (0.44) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL6367373 | 0.75 | MAPT (0.59) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL10552543 | 0.75 | MAPT (0.46) | MAPTALDH1A1KMT2ANPC1ABCB1 | |
| SCHEMBL12660084 | 0.74 | NPC1 (0.62) | MAPTKMT2ANPC1RAB9AMAPK1 | |
| SCHEMBL5569675 | 0.73 | MAPT (0.57) | MAPTALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL2213047 | 0.73 | ALDH1A1 (0.60) | MAPTALDH1A1KMT2ANPC1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |