Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369720 | 1.00 | RAB9A (0.57) | RAB9ANPC1L3MBTL1MEN1KMT2A | |
| SCHEMBL6214067 | 0.88 | UTS2R (0.57) | NPC1MAPTALDH1A1CYP3A4GAA | |
| SCHEMBL6214070 | 0.88 | UTS2R (0.57) | NPC1MAPTALDH1A1CYP3A4GAA | |
| SCHEMBL6213961 | 0.87 | ALDH1A1 (0.60) | RAB9ANPC1ALDH1A1CYP3A4GAA | |
| SCHEMBL6215659 | 0.87 | ALDH1A1 (0.60) | RAB9ANPC1ALDH1A1CYP3A4GAA | |
| SCHEMBL6218271 | 0.86 | TAOK1 (0.55) | RAB9ANPC1ALDH1A1CYP3A4GAA | |
| SCHEMBL6218266 | 0.86 | TAOK1 (0.55) | RAB9ANPC1ALDH1A1CYP3A4GAA | |
| SCHEMBL6215488 | 0.81 | KDM4E (0.55) | MAPTALDH1A1LMNACYP3A4GAA | |
| SCHEMBL28398270 | 0.80 | NPC1 (0.61) | RAB9ANPC1L3MBTL1MEN1KMT2A | |
| SCHEMBL5867892 | 0.79 | ROCK1 (0.62) | RAB9ANPC1ALDH1A1MAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855715-B1 | Serine protease inhibitors | ELI LILLY AND COMPANY (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |