Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.69 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9225238 | 1.00 | PDE3B (0.69) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL10353457 | 0.87 | PDE3B (0.71) | PDE3BPDE3ATNNC1PDE4APDE4B | |
| SCHEMBL28430822 | 0.85 | PDE3B (0.69) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL5677157 | 0.85 | PDE3B (0.69) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL5679082 | 0.85 | PDE3B (0.69) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL7264551 | 0.85 | PDE3B (0.64) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL16157013 | 0.83 | PDE3B (0.66) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL3723997 | 0.82 | PDE3B (1.00) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL11489732 | 0.82 | PDE3B (0.64) | PDE3BPDE3ATNNC1KDM4EALDH1A1 | |
| SCHEMBL3723998 | 0.82 | PDE3B (1.00) | PDE3BPDE3ATNNC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | KCNJ2, KCNN2, KCNK2 | PDE3B 990/4885PDE3A 1225/4885TNNC1 689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.