Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736704 | 1.00 | L3MBTL1 (0.39) | L3MBTL1GRM5L3MBTL3ALDH1A1SMN1; SMN2 | |
| SCHEMBL738007 | 0.94 | L3MBTL1 (0.40) | L3MBTL1GRM5L3MBTL3ALDH1A1SMN1; SMN2 | |
| SCHEMBL736051 | 0.87 | L3MBTL1 (0.44) | L3MBTL1GRM5L3MBTL3ALDH1A1SMN1; SMN2 | |
| SCHEMBL735235 | 0.82 | CYP2D6 (0.33) | L3MBTL1L3MBTL3 | |
| SCHEMBL739014 | 0.80 | CYP2D6 (0.32) | L3MBTL1L3MBTL3 | |
| SCHEMBL737923 | 0.80 | CYP2D6 (0.32) | L3MBTL1L3MBTL3 | |
| SCHEMBL736026 | 0.80 | CYP2D6 (0.32) | L3MBTL1L3MBTL3 | |
| SCHEMBL9789988 | 0.80 | L3MBTL1 (0.41) | L3MBTL1GRM5L3MBTL3ALDH1A1SMN1; SMN2 | |
| SCHEMBL206897 | 0.78 | CYP2D6 (0.33) | L3MBTL1L3MBTL3 | |
| SCHEMBL4159670 | 0.78 | CYP2D6 (0.33) | L3MBTL1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | KCNJ2, KCNN2, KCNK2 | L3MBTL1 4530/4885GRM5 210/4885L3MBTL3 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.