Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | CDK1 | P06493 | 3/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.61 |
| ▸ | LYN | P07948 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | MARK3 | P27448 | 2/20 | 0.61 |
| ▸ | BLK | P51451 | 2/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.61 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15968669 | 0.97 | AURKA (0.63) | AURKAMAPTMAPK1CDK1PRKCD | |
| SCHEMBL911 | 0.97 | AURKA (0.63) | AURKAMAPTMAPK1CDK1PRKCD | |
| Hydrochloric Acid SCHEMBL6820971 | 0.95 | MAPK1 (0.61) | AURKAMAPTMAPK1CDK1PRKCD | |
| Ammonia Solution, Strong SCHEMBL28789700 | 0.95 | MAPT (0.61) | AURKAMAPTMAPK1CDK1PRKCD | |
| Pyrimidine SCHEMBL27837500 | 0.87 | MAPT (0.53) | AURKAMAPTMAPK1CDK1PRKCD | |
| SCHEMBL29484614 | 0.85 | MAPT (0.52) | AURKAMAPTMAPK1CDK1PRKCD | |
| SCHEMBL27835195 | 0.84 | PRKCD (0.50) | AURKAMAPTMAPK1CDK1PRKCD | |
| Pyrimethanil SCHEMBL1467035 | 0.80 | SMN1; SMN2 (0.61) | AURKAMAPTMAPK1CDK1PRKCD | |
| SCHEMBL5823445 | 0.80 | RAD52 (0.48) | AURKAMAPTMAPK1CDK1PRKCD | |
| SCHEMBL27753867 | 0.79 | AURKA (0.46) | AURKAMAPTMAPK1CDK1PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009849-A1 | Pyridopyrimidine kinase inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2005-01-13 | — | — | US | disclosed |
| WO-2004063195-A1 | PYRIDOPYRIMIDINE KINASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009849-A1 | Pyridopyrimidine kinase inhibitors | MAP3K1, MAP3K19, MAP3K20 | AURKA 52/4885MAPT 2735/4885MAPK1 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.