Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.82 |
| ▸ | CA9 | Q16790 | 3/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.68 |
| ▸ | CA1 | P00915 | 2/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.68 |
| ▸ | PTGES | O14684 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.68 |
| ▸ | PDE5A | O76074 | 1/20 | 0.68 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CA3 | P07451 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213150 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL5423345 | 0.89 | PTGS2 (0.73) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL6339098 | 0.88 | PTGS2 (0.72) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL2602400 | 0.85 | PTGS2 (0.80) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL212919 | 0.84 | CYP2C9 (0.90) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL5430454 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL5424001 | 0.83 | PTGS2 (0.70) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL3869967 | 0.82 | PTGS2 (0.68) | PTGS2PTGS1CA9PDPK1CA1 | |
| SCHEMBL27476191 | 0.81 | CA9 (0.76) | PTGS2PTGS1CA9PDPK1CA1 | |
| Celecoxib SCHEMBL3669597 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1CA9PDPK1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075359-A1 | Large conductance calcium-activated K channel opener | TANABE SEIYAKU CO., LTD. (JP) | 2005-04-07 | — | — | US | claimed |
| EP-1400243-A1 | Calcium-activated K channel activator | TANABE SEIYAKU CO., LTD. (JP) | 2004-03-24 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075359-A1 | Large conductance calcium-activated K channel opener | KCNN3, KCNN2, KCNN1 | PTGS2 806/4885PTGS1 760/4885CA9 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.