Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29334052 | 0.80 | HPGD (0.55) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL256310 | 0.78 | HPGD (0.59) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL21189714 | 0.78 | HPGD (0.58) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL31536222 | 0.77 | HPGD (0.59) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL2104229 | 0.76 | HPGD (0.59) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5094255 | 0.76 | L3MBTL3 (0.58) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL31536263 | 0.75 | HPGD (0.54) | GAAHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL21608579 | 0.75 | KDM4E (0.65) | GAAHPGDALDH1A1KMT2ATSHR | |
| SCHEMBL2154955 | 0.74 | KDM4E (0.46) | ALDH1A1MEN1KMT2ATSHRHTT | |
| SCHEMBL221718 | 0.74 | KDM4E (0.66) | MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |