⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293682 | 0.82 | CYP11B1 (0.44) | — | |
| SCHEMBL3291803 | 0.73 | — | — | |
| SCHEMBL31227033 | 0.71 | — | — | |
| SCHEMBL2632677 | 0.71 | — | — | |
| SCHEMBL19555999 | 0.71 | — | — | |
| SCHEMBL11370784 | 0.71 | — | — | |
| SCHEMBL21664084 | 0.71 | — | — | |
| SCHEMBL945452 | 0.71 | — | — | |
| SCHEMBL16369773 | 0.71 | IRAK4 (0.40) | — | |
| Ammonia Solution, Strong SCHEMBL28120837 | 0.70 | CYP11B1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100390153-C | Intermediate for producing novel pyrazine derivatives | TOYAMA CHEMICAL CO LTD (JP) | 2008-05-28 | — | — | CN | disclosed |
| CN-1781911-A | Intermediate for producing novel pyrazine derivatives | TOYAMA CHEMICAL CO LTD (JP) | 2006-06-07 | — | — | CN | disclosed |
| CN-1239511-C | Novel pyrazine derivative or salt thereof, and pharmaceutical composition containing the same | TOYAMA CHEMICAL CO LTD (JP) | 2006-02-01 | — | — | CN | disclosed |
| EP-1295890-B1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | TOYAMA CHEMICAL CO LTD (JP) | 2005-04-27 | — | — | EP | disclosed |
| EP-1256588-B1 | NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH | TOYAMA CHEMICAL CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6800629-B2 | VIRICIDES | TOYAMA CHEMICAL CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| US-20030130213-A1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2003-07-10 | — | — | US | disclosed |
| CN-1418220-A | Novel pyrazine derivative or salt thereof, pharmaceutical composition containing same, and intermediate for producing both | TOYAMA CHEMICAL CO LTD (JP) | 2003-05-14 | — | — | CN | disclosed |
| EP-1295890-A1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2003-03-26 | — | — | EP | disclosed |
| EP-1256588-A1 | NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-11-13 | — | — | EP | disclosed |