SCHEMBL945452

SCHEMBL945452

N#Cc1cncc(Cl)n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3293682 0.82 CYP11B1 (0.44)
SCHEMBL376303 0.76
SCHEMBL2370987 0.73 CDK2 (0.41)
SCHEMBL138054 0.73
SCHEMBL11370784 0.71
SCHEMBL21664084 0.71
SCHEMBL27851416 0.71 CYP11B1 (0.42)
SCHEMBL6375657 0.71
SCHEMBL31227033 0.71
SCHEMBL19555999 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108083599-A For the foam Ti-base catalyst of sludge hot hydrolysis process system 北京达源环保科技有限公司 2018-05-29 CN claimed
EP-3898646-B1 3.ALPHA.-HYDROXY-17.BETA.-AMIDE NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF SAGE THERAPEUTICS LLC (US) 2026-02-18 EP disclosed
US-20260000692-A1 Substituted N-(Pyridin-2-yl)Acetamide Derivatives as CDK12/13 Inhibitors AURIGENE ONCOLOGY LIMITED (IN) 2026-01-01 US disclosed
US-12398139-B2 Modulators of AMPA receptor signaling CENTRE FOR ADDICTION AND MENTAL HEALTH (CA) 2025-08-26 US disclosed
EP-4594318-A1 AKT1 MODULATORS Alterome Therapeutics, Inc. (US) 2025-08-06 EP disclosed
EP-4590396-A1 PCSK9 INHIBITORS AND METHODS OF USE THEREOF Astrazeneca AB (SE) 2025-07-30 EP disclosed
US-20250197421-A1 MCL1 INHIBITORS GILEAD SCIENCES, INC. 2025-06-19 US disclosed
WO-2025092989-A1 SUBSTITUTED QUINAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMBINATION THEREOF, AND USE THEREOF 泰州红云制药有限公司 2025-05-08 WO disclosed
EP-3935059-B1 MODULATORS OF AMPA RECEPTOR SIGNALING CAMH (CA) 2025-04-23 EP disclosed
US-20250092040-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2025-03-20 US disclosed
EP-1256588-A1 NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH TOYAMA CHEMICAL CO., LTD. (JP) 2002-11-13 EP disclosed
US-20020165241-A1 N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists MERCK SHARP & DOHME LLC 2002-11-07 US disclosed
WO-2002068409-A1 N-SUBSTITUTED NONARYL-HETEROCYCLIC NMDA/NR2B ANTAGONISTS MERCK & CO., INC. (US) 2002-09-06 WO disclosed
EP-0747486-B1 Microbiological method for the synthesis of heteroaromatic caboxylic acids using microorganisms of the genus Alcaligenes LONZA AG (CH) 1999-11-03 EP disclosed
US-5702930-A FROM CORRESPONDING NITRILE COMPOUND LONZA, LTD. (CH) 1997-12-30 US disclosed
EP-0747486-A1 Microbiological method for the synthesis of heteroaromatic caboxylic acids using microorganisms of the genus Alcaligenes LONZA AG (CH) 1996-12-11 EP disclosed
EP-0182111-B1 PROCESS FOR THE PREPARATION OF PERHALOGENATED COMPOUNDS BASF Aktiengesellschaft (DE) 1989-09-20 EP disclosed
US-4293552-A Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas ELI LILLY AND COMPANY (US) 1981-10-06 US disclosed
US-4160834-A INSECTICIDES ELI LILLY AND COMPANY (US) 1979-07-10 US disclosed
US-4083977-A Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas ELI LILLY AND COMPANY (US) 1978-04-11 US disclosed