Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | PDE2A | O00408 | 4/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5410449 | 0.93 | PDE3B (0.46) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL6169519 | 0.88 | PDE3B (0.40) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL5408066 | 0.85 | PDE3B (0.47) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL5426529 | 0.84 | PDE3B (0.47) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL6169099 | 0.81 | PDE3B (0.45) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL6167487 | 0.81 | PDE3B (0.46) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL5413243 | 0.81 | PDE3B (0.50) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL6369472 | 0.80 | PDE3B (0.46) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL5415370 | 0.79 | PDE3B (0.51) | PDE3BPDE3APDE2AP2RY12PDE10A | |
| SCHEMBL6168820 | 0.79 | PDE3B (0.45) | PDE3BPDE3APDE2AP2RY12PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143439-A1 | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143439-A1 | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | MSR1, ARG2, CYBB | PDE3B 323/4885PDE3A 386/4885PDE2A 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.