Known targets — ChEMBL curated mechanism
CHRNA10CHRNA9GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Neramexane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931548 | 0.78 | — | — | |
| SCHEMBL635941 | 0.74 | ESR1 (0.35) | — | |
| SCHEMBL339609 | 0.74 | — | — | |
| SCHEMBL20756316 | 0.74 | — | — | |
| SCHEMBL8941973 | 0.72 | CA2 (0.30) | — | |
| SCHEMBL6032874 | 0.69 | — | — | |
| Hydrazine SCHEMBL6945698 | 0.64 | — | — | |
| Hydrazine SCHEMBL5543279 | 0.64 | CA2 (0.50) | — | |
| Hydroxyamine SCHEMBL5552814 | 0.64 | — | — | |
| Methylamine SCHEMBL330884 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8834924-B2 | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2014-09-16 | — | — | US | disclosed |
| US-20120100184-A1 | SYNTHESIS OF 1-AMINO-1,3,3,5,5,-CYCLOHEXANE MESYLATE | MERZ PHARMA GMBH & CO.KGAA (DE) | 2012-04-26 | — | — | US | disclosed |
| US-20120093866-A1 | FORMULATION FOR STABILIZING PROTEINS, WHICH IS FREE OF MAMMALIAN EXCIPIENT | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-19 | — | — | US | disclosed |
| EP-2419402-A1 | SYNTHESIS OF 1-AMINO-1,3,3,5,5-PENTAMETHYLCYCLOHEXANE MESYLATE | Merz Pharma GmbH & Co. KGaA (DE) | 2012-02-22 | — | — | EP | disclosed |
| US-20110236439-A1 | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-09-29 | — | — | US | disclosed |