Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 8/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 8/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378379 | 0.92 | SLC7A5 (0.43) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL6378384 | 0.85 | ALDH1A1 (0.48) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL6377823 | 0.85 | ALDH1A1 (0.48) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL8326453 | 0.85 | CDC25B (0.37) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL6655287 | 0.85 | SLC7A5 (0.45) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL6947602 | 0.84 | PTGER4 (0.43) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL6383755 | 0.83 | MEN1 (0.48) | HDAC1LPAR1LPAR5HDAC6RCE1 | |
| SCHEMBL27334618 | 0.81 | ALDH1A1 (0.41) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL8326411 | 0.81 | LPAR1 (0.38) | HDAC1HDAC3HDAC2NCOR2LPAR1 | |
| SCHEMBL9823156 | 0.80 | HDAC1 (0.54) | HDAC1HDAC3HDAC2NCOR2LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225895-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2005-05-04 | — | — | EP | disclosed |
| US-6762201-B1 | SUCH AS N-((2-AMINO-5-(N-METHYL-N-((1-METHYLINDOL-2-YL) -METHYL)CARBAMOYL)PHENYL)METHYL)-N-METHYLACETAMIDE; BACTERIAL INFECTIONS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-07-13 | — | — | US | disclosed |