Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PLEC | Q15149 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327800 | 0.91 | ALOX15 (0.38) | HDAC3HDAC1HDAC2NCOR2SSTR4 | |
| SCHEMBL8327876 | 0.84 | POLB (0.44) | ALDH1A1 | |
| SCHEMBL8327873 | 0.84 | POLB (0.44) | ALDH1A1 | |
| SCHEMBL8326453 | 0.83 | CDC25B (0.37) | LPAR1LPAR5CDC25BHDAC3HDAC1 | |
| SCHEMBL6947602 | 0.82 | PTGER4 (0.43) | CDC25BHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL28609267 | 0.82 | HDAC3 (0.38) | CDC25BHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL6941296 | 0.82 | CDC25B (0.42) | CDC25BHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL6376540 | 0.81 | HDAC1 (0.43) | LPAR1LPAR5HDAC3HDAC1HDAC2 | |
| SCHEMBL7425320 | 0.76 | KDM4E (0.38) | CDC25BHDAC3KDM4EALDH1A1GAA | |
| SCHEMBL8326945 | 0.75 | KMT2A (0.40) | ALDH1A1MAPTTHRBHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |