Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.58 |
| ▸ | PPARA | Q07869 | 10/20 | 0.58 |
| ▸ | PPARD | Q03181 | 3/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | MPC2 | O95563 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6374920 | 0.91 | PPARA (0.57) | PPARGPPARAPPARDPTPN1FFAR1 | |
| SCHEMBL6376924 | 0.90 | PPARA (0.60) | PPARGPPARAPPARDPTPN1MPC2 | |
| SCHEMBL13524845 | 0.88 | PTPN1 (0.55) | PPARGPPARAPPARDPTPN1CA2 | |
| SCHEMBL6233615 | 0.88 | PTPN1 (0.51) | PPARGPPARAPPARDPTPN1MPC2 | |
| SCHEMBL13847876 | 0.88 | PTPN1 (0.54) | PPARGPPARAPPARDPTPN1MPC2 | |
| SCHEMBL6231739 | 0.87 | PPARA (0.55) | PPARGPPARAPTPN1CA2HPGD | |
| SCHEMBL6378335 | 0.86 | FFAR1 (0.55) | PPARGPPARAPTPN1FFAR1TP53 | |
| SCHEMBL6376424 | 0.86 | POLB (0.54) | PPARGPPARAPPARDPTPN1CA2 | |
| SCHEMBL20125593 | 0.84 | PPARA (0.61) | PPARGPPARAPPARDPTPN1 | |
| SCHEMBL14379043 | 0.84 | PPARA (0.61) | PPARGPPARAPPARDPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1207157-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-06-01 | — | — | EP | claimed |
| US-6734199-B1 | SUCH AS N-((4-BENZYLOXYPHENYL)-METHYL)-5-((2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL)-2 -METHOXYBENZAMIDE, HYPOGLYCEMIC AND LIPID LOWERING EFFECT VIA PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-11 | — | — | US | claimed |
| EP-1207157-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-22 | — | — | EP | claimed |
| EP-1207157-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-06-01 | — | — | EP | disclosed |
| EP-1207157-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-22 | — | — | EP | disclosed |