Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.82 |
| ▸ | VCP | P55072 | 1/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.82 |
| ▸ | PNP | P00491 | 6/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | HBB | P68871 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | EDNRA | P25101 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HPRT1 | P00492 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ganciclovir SCHEMBL2160505 | 0.90 | BLM (1.00) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL3033 | 0.90 | BLM (1.00) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL10481436 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL10481442 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL10901635 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL25915 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL11093368 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL1242615 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL10899902 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA | |
| Ganciclovir SCHEMBL11121521 | 0.89 | BLM (0.98) | BLMMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714691-B1 | PROCESS FOR THE PREPARATION OF 2-AMINO-9-((2-PHENYL-1,3-DIOXAN-5-YLOXY)METHYL)-1H-PURIN-6(9H)-ONE COMPOUND USEFUL IN THE PREPARATION OF VALGANCICLOVIR | PHARMATHEN SA (GR) | 2016-09-07 | — | — | EP | disclosed |
| CN-103562207-B | For preparing the preparation method of 2-amino-9-((2-phenyl-1,3-dioxane-5-base epoxide) methyl)-1H-purine-6 (9H) the-one compound of valganciclovir | 法尔玛赞公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103562207-A | Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir | PHARMATHEN SA | 2014-02-05 | — | — | CN | disclosed |
| WO-2012163373-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-9-((2-PHENYL-1,3-DIOXAN-5-YLOXY)METHYL)-1H-PURIN-6(9H)-ONE COMPOUND USEFUL IN THE PREPARATION OF VALGANCICLOVIR | PHARMATHEN S.A. (GR) | 2012-12-06 | — | — | WO | disclosed |
| EP-0882050-B2 | PROCESS FOR PREPARING PURINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2005-05-04 | — | — | EP | disclosed |
| EP-0882050-B1 | PROCESS FOR PREPARING PURINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2002-08-28 | — | — | EP | disclosed |
| US-6340756-B1 | VIRICIDES | SYNTEX (U.S.A.) INC. | 2002-01-22 | — | — | US | disclosed |
| CN-1064683-C | Process for preparing purine derivatives | HOFFMANN LA ROCHE (CH) | 2001-04-18 | — | — | CN | disclosed |
| US-6218568-B1 | REACTING 1-ARALKYLOXY-3-HALO-2-PROPANOL WITH METHOXYMETHYL ALKANOATE IN APROTIC SOLVENT IN THE PRESENCE OF A CATALYST TO PRODUCE 1-ARALKYLOXY-3-HALO-2-(ALKANOYLOXY)METHOXYPROPANE AND TREATING THE PRODUCT WITH ALKALI METAL ALKANOATE | SYNTEX (U.S.A.) INC. | 2001-04-17 | — | — | US | disclosed |
| US-6215017-B1 | 1-ARALKYLOXY-3-ACYLOXY-2-(ACYLOXY)METHOXYPROPANE DERIVATIVE; CHEMICAL INTERMEDIATES FOR VIRICIDE GANCICLOVIR | SYNTEX (U.S.A.) INC. | 2001-04-10 | — | — | US | disclosed |
| US-6040446-A | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative | SYNTEX (U.S.A.) INC. (US) | 2000-03-21 | — | — | US | disclosed |
| CN-1212693-A | Process for preparing purine derivatives | HOFFMANN LA ROCHE (CH) | 1999-03-31 | — | — | CN | disclosed |
| EP-0882050-A1 | PROCESS FOR PREPARING PURINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997027198-A1 | PROCESS FOR PREPARING PURINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-07-31 | — | — | WO | disclosed |