Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.35 |
| ▸ | HTR2A | P28223 | 7/20 | 0.35 |
| ▸ | HTR2B | P41595 | 7/20 | 0.35 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | HTR1D | P28221 | 5/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.30 |
| ▸ | WNT3A | P56704 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320521 | 0.89 | KIF11 (0.34) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL63494 | 0.77 | HTR2C (0.35) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL1143507 | 0.73 | HTR2C (0.45) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL62556 | 0.71 | ITGB2 (0.36) | ADRA2AADRA2CMTNR1A | |
| SCHEMBL13035776 | 0.71 | HTR2C (0.43) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL436160 | 0.71 | MAP3K14 (0.46) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL64098 | 0.70 | — | — | |
| SCHEMBL13861841 | 0.68 | HTR2C (0.38) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL14405274 | 0.68 | HTR2C (0.38) | HTR2CHTR2AHTR2BHTR1AHTR1D | |
| SCHEMBL18288209 | 0.68 | HTR2C (0.41) | HTR2CHTR2AHTR2BHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392561-B1 | Alpha-acylaminoketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORP (US) | 2016-09-14 | — | — | EP | claimed |
| EP-1534658-B1 | KETONE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | INTREXON CORP (US) | 2016-09-07 | — | — | EP | claimed |
| US-8129355-B2 | Nuclear receptor-based inducible gene expression system; modulating the expression of a gene in a host cell by introducing into the host cell a gene expression modulation system and activating that system using 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (1-benzoyl-cyclopentyl)-amide | INTREXON CORPORATION (US) | 2012-03-06 | — | — | US | claimed |
| EP-2392561-A1 | Alpha-acylaminoketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | Intrexon Corporation (US) | 2011-12-07 | — | — | EP | claimed |
| US-20090111183-A1 | Ketone Ligands for Modulating the Expression of Exogenous Genes Via An Ecdysone Receptor Complex | RHEOGENE, INC. | 2009-04-30 | — | — | US | claimed |
| CN-100475033-C | Cyclopropene supply system | ROHM & HAAS (US) | 2009-04-08 | — | — | CN | claimed |
| US-20080125465-A1 | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORPORATION (US) | 2008-05-29 | — | — | US | claimed |
| US-7375093-B2 | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORPORATION (US) | 2008-05-20 | — | — | US | claimed |
| EP-1534658-A4 | KETONE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | RHEOGENE INC (US) | 2006-10-04 | — | — | EP | claimed |
| CN-1219752-C | Process for preparing substituted hydrazide by using carboxylic acid | DOW AGROSCIENCES LLC (US) | 2005-09-21 | — | — | CN | claimed |
| US-20030065192-A1 | Antimicrobial compounds and methods of use | GHOSH TIRTHANKAR (US) | 2003-04-03 | — | — | US | claimed |
| EP-0982292-B1 | Process for the preparation of monoacylhydrazines using carboxylic acids | DOW AGROSCIENCES LLC (US) | 2003-03-26 | — | — | EP | claimed |
| CN-1365609-A | Antimicrobe compound and its use method | ROHM & HAAS (US) | 2002-08-28 | — | — | CN | claimed |
| EP-1223171-A1 | Antimicrobial 5-substituted-3-isothiazolone compounds and methods of use | Rohm and Haas (US) | 2002-07-17 | — | — | EP | claimed |
| US-6096890-A | Process for substituted hydrazides using carboxylic acids | ROHM AND HAAS COMPANY (US) | 2000-08-01 | — | — | US | claimed |
| CN-1248576-A | Process for preparing substituted hydrazide by using carboxylic acid | ROHM & HAAS (US) | 2000-03-29 | — | — | CN | claimed |
| EP-0982292-A2 | Process for the preparation of monoacylhydrazines using carboxylic acids | ROHM AND HAAS COMPANY (US) | 2000-03-01 | — | — | EP | claimed |
| US-5672723-A | SELECTIVE HYDROLYSIS OR ALCOHOLYSIS OF A MIXTURE OF 1-ACYL-1-ALKYLHYDRAZINE AND 1-ACYL-2-ALKYLHYDRAZINE USING AN ACID CATALYST TO OBTAIN AN ACID OR ESTER AND THE STABLE 1-ACYL-2-ALKYLHYRAZINE | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1997-09-30 | — | — | US | claimed |
| EP-0639558-B1 | Process for preparation of 1-acyl-2-substituted-hydrazines | NIPPON KAYAKU KK (JP) | 1996-10-23 | — | — | EP | claimed |
| EP-0639558-A1 | Process for preparation of 1-acyl-2-substituted-hydrazines | Nippon Kayaku Kabushiki Kaisha (JP) | 1995-02-22 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111183-A1 | Ketone Ligands for Modulating the Expression of Exogenous Genes Via An Ecdysone Receptor Complex | ESRRB, ESRRA, KDELR1 | HTR2C 4270/4885HTR2A 3752/4885HTR2B 4349/4885 |
| US-20030065192-A1 | Antimicrobial compounds and methods of use | TST, NISCH, PIR | HTR2C 2376/4885HTR2A 4298/4885HTR2B 3450/4885 |
| US-20080125465-A1 | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | ESRRB, ESRRA, KDELR1 | HTR2C 4270/4885HTR2A 3752/4885HTR2B 4349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.