Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 7/20 | 0.51 |
| ▸ | UBE2I | P63279 | 7/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 7/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 7/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6372842 | 0.86 | ADORA2A (0.51) | ADORA2AADORA1CACNA1BAPBA1UBE2I | |
| SCHEMBL6374076 | 0.84 | ADORA2A (0.59) | ADORA2AADORA1CACNA1BAPBA1UBE2I | |
| SCHEMBL6372614 | 0.84 | KDM4E (0.42) | ADORA2AADORA1CACNA1BAPBA1UBE2I | |
| SCHEMBL6374911 | 0.83 | HPGD (0.46) | ADORA2AADORA1CACNA1BAPBA1UBE2I | |
| SCHEMBL6371594 | 0.75 | LMNA (0.53) | ALDH1A1SMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL6372925 | 0.75 | ADORA2A (0.59) | ADORA2AADORA1CACNA1BAPBA1UBE2I | |
| SCHEMBL28523876 | 0.72 | CACNA1B (0.76) | ADORA2AADORA1CACNA1BAPBA1UBE2I | |
| SCHEMBL5528074 | 0.72 | MAPT (0.61) | ALDH1A1SMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL6374732 | 0.72 | LMNA (0.56) | ALDH1A1KDM4ESMN1; SMN2MAPTLMNA | |
| SCHEMBL6374798 | 0.72 | LMNA (0.55) | ALDH1A1SMN1; SMN2MAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176767-A1 | Pyridine carboxamide and methods for inhibiting HIV integrase | VIRO CHEM PHARMA, INC. (CA) | 2005-08-11 | — | — | US | disclosed |
| WO-2005042524-A1 | PYRIDINE CARBOXAMIDE AND METHODS FOR INHIBITING HIV INTEGRASE | VIROCHEM PHARMA INC. (CA) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176767-A1 | Pyridine carboxamide and methods for inhibiting HIV integrase | PARP10, QTRT1, NQO2 | ADORA2A 1852/4885ADORA1 345/4885CACNA1B 1703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.