Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 10/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378851 | 0.82 | MMP13 (0.47) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6383331 | 0.80 | MMP13 (0.54) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6378753 | 0.77 | MMP13 (0.49) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6375133 | 0.76 | CA12 (0.56) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6383052 | 0.76 | MMP13 (0.48) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6378913 | 0.75 | MMP13 (0.56) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6379245 | 0.74 | CTSL (0.48) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6378849 | 0.74 | MMP13 (0.47) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6379189 | 0.73 | CTSL (0.49) | MMP13MMP2CTSLCTSBMAOB | |
| SCHEMBL6379044 | 0.72 | MMP13 (0.50) | MMP13MMP2CTSLCTSBMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202974-B1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6579982-B1 | Treating inflammation, cancer | PFIZER INC. | 2003-06-17 | — | — | US | disclosed |
| EP-1202974-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012611-A1 | PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2001-02-22 | — | — | WO | disclosed |