SCHEMBL6380792

SCHEMBL6380792

Cc1ccc(C2C(=O)NC(=O)NC2=O)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.48
KMT2A Q03164 5/20 0.48
HTT P42858 1/20 0.46
MAPT P10636 3/20 0.42
NPSR1 Q6W5P4 2/20 0.42
ATM Q13315 1/20 0.42
HAO1 Q9UJM8 1/20 0.38
GAA P10253 4/20 0.38
KDM4E B2RXH2 4/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.37
TNKS2 Q9H2K2 1/20 0.37
F2 P00734 1/20 0.37
ELANE P08246 1/20 0.37
CTSG P08311 1/20 0.37
CMA1 P23946 1/20 0.37
CTRC Q99895 1/20 0.37
ALDH1A1 P00352 4/20 0.36
DDB1 Q16531 1/20 0.36
CRBN Q96SW2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31579572 0.78 HAO1 (0.59) MEN1KMT2AMAPTHAO1GAA
SCHEMBL6381012 0.78 KDM4E (0.48) MEN1KMT2AHAO1KDM4ESMN1; SMN2
SCHEMBL6385836 0.78 HPGD (0.53) KMT2AMAPTGAAKDM4ESMN1; SMN2
SCHEMBL1639992 0.77 MAPT (0.48) MEN1KMT2AMAPTGAASMN1; SMN2
SCHEMBL297089 0.76 KMT2A (0.49) MEN1KMT2AMAPTATMGAA
SCHEMBL17294198 0.76 MAPT (0.46) MEN1KMT2AMAPTGAASMN1; SMN2
SCHEMBL27489956 0.75 DDB1 (0.41) MAPTHAO1GAATDP1DDB1
SCHEMBL9690927 0.75 TDP1 (0.67) MEN1KMT2AHTTMAPTNPSR1
SCHEMBL14466166 0.75 TDP1 (0.67) MEN1KMT2AHTTMAPTNPSR1
SCHEMBL31579581 0.74 TSHR (0.46) SMN1; SMN2ALDH1A1DDB1CRBNALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0989982-B1 BARBITURIC ACID DERIVATIVES WITH ANTIMETASTATIC AND ANTITUMOR ACTIVITY ROCHE DIAGNOSTICS GMBH (DE) 2005-08-17 EP disclosed
US-6472396-B1 Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds ROCHE DIAGNOSTICS GMBH (DE) 2002-10-29 US disclosed
EP-0869947-B1 BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2002-10-23 EP disclosed
US-6335332-B1 MATRIX METALLOPROTEASE INHIBITORS; CONTRACEPTIVES, ANTIINFLAMMATORY AGENTS ROCHE DIAGNOSTICS GMBH (DE) 2002-01-01 US disclosed
US-6110924-A MATRIX METALLOPROTEASE INHIBITORS ROCHE DIAGNOSTICS GMBH (DE) 2000-08-29 US disclosed
EP-0869947-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1998-10-14 EP disclosed
WO-1997023465-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1997-07-03 WO disclosed