Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5719452 | 0.92 | LMNA (0.39) | LMNAALDH1A1NPSR1TSHRPOLB | |
| SCHEMBL5719066 | 0.85 | BACE1 (0.36) | LMNAHTTADORA3MAOBTP53 | |
| SCHEMBL5719564 | 0.83 | TSHR (0.38) | LMNAALDH1A1NPSR1TSHRPOLB | |
| SCHEMBL5718966 | 0.82 | ALDH1A1 (0.46) | LMNAALDH1A1NPSR1TSHRPOLB | |
| SCHEMBL5719876 | 0.81 | LMNA (0.45) | LMNAALDH1A1NPSR1TSHRPOLB | |
| SCHEMBL6409570 | 0.81 | MAOB (0.38) | LMNAALDH1A1NPSR1TSHRADORA3 | |
| SCHEMBL5719669 | 0.81 | LMNA (0.37) | LMNAALDH1A1NPSR1TSHRPOLB | |
| SCHEMBL6424057 | 0.79 | DPP4 (0.39) | LMNAALDH1A1NPSR1TSHR | |
| SCHEMBL5718924 | 0.78 | BACE1 (0.41) | LMNAHTTADORA3MAOBTP53 | |
| SCHEMBL5788736 | 0.78 | LMNA (0.48) | LMNAALDH1A1NPSR1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1557165-A1 | COMBINATION DRUG | Eisai Co., Ltd. (JP) | 2005-07-27 | — | — | EP | disclosed |