Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384160 | 0.81 | CA12 (0.45) | CSNK2A2CSNK2BCSNK2A1KDRSMN1; SMN2 | |
| SCHEMBL6383174 | 0.78 | CA12 (0.44) | CNR2CSNK2A2CSNK2BCSNK2A1KDR | |
| SCHEMBL3786249 | 0.78 | SMN1; SMN2 (0.45) | RXFP1SMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL3791523 | 0.77 | SMN1; SMN2 (0.47) | RXFP1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4470283 | 0.77 | NPC1 (0.42) | RXFP1SMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL5224142 | 0.75 | POLB (0.60) | RXFP1SMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL6076256 | 0.74 | SMN1; SMN2 (0.41) | RXFP1SMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL2733475 | 0.73 | SMN1; SMN2 (0.42) | RXFP1SMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL2880191 | 0.71 | LMNA (0.54) | CNR2RXFP1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL6076142 | 0.70 | AKT1 (0.37) | RXFP1SMN1; SMN2LMNAMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592667-A2 | NEW MONO-ACYLATED O-PHENYLENDIAMINES DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004069803-A2 | MONO-ACYLATED O-PHENYLENDIAMINES DERIVATIVES AND THEIR USE AGAINST CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |