Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880194 | 0.93 | BRD9 (0.52) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL736662 | 0.93 | POLB (0.49) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL15711990 | 0.91 | LMNA (0.48) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL22735089 | 0.89 | LMNA (0.47) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL1534089 | 0.89 | NPC1 (0.58) | LMNAPOLBRXFP1BRD9ALDH1A1 | |
| SCHEMBL2940952 | 0.89 | GAA (0.51) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL1794452 | 0.89 | LMNA (0.49) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL21251514 | 0.88 | SMN1; SMN2 (0.47) | LMNAPOLBRXFP1BRD9ALDH1A1 | |
| SCHEMBL21232396 | 0.88 | LMNA (0.46) | LMNAPOLBRXFP1BRD9METAP1 | |
| SCHEMBL6811831 | 0.88 | SMN1; SMN2 (0.51) | LMNAPOLBRXFP1BRD9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |