Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 12/20 | 1.00 |
| ▸ | PDE4A | P27815 | 5/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424162 | 0.89 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6190255 | 0.86 | TNF (0.76) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17682312 | 0.86 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL316911 | 0.82 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8861573 | 0.82 | TNF (0.82) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381262 | 0.81 | PDE4A (0.91) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381251 | 0.80 | PDE4A (0.89) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381243 | 0.77 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8644270 | 0.76 | TNF (0.79) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17682325 | 0.75 | TNF (0.80) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1193257-B1 | Compounds for ceramide-mediated signal transduction | UNIV CALIFORNIA (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-0801568-B1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1193257-A2 | Compounds for ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5843943-A | Compounds for inhibition of ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801568-A4 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 1998-02-25 | — | — | EP | disclosed |
| EP-0801568-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996020710-A1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-07-11 | — | — | WO | disclosed |