Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 10/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17682312 | 0.96 | TNF (1.00) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL6384593 | 0.89 | TNF (1.00) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL17682325 | 0.85 | TNF (0.80) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL8644270 | 0.85 | TNF (0.79) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL18819562 | 0.84 | TNF (0.75) | TNFADORA2BUSP2LMNACYP1A2 | |
| 1-[4-Carboxypropyl]-3,7-Dimethylxanthine SCHEMBL5420399 | 0.84 | ADORA2B (0.74) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL10519753 | 0.84 | ADORA2B (0.92) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL17682215 | 0.83 | TNF (0.77) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL8861573 | 0.83 | TNF (0.82) | TNFADORA2BUSP2LMNACYP1A2 | |
| SCHEMBL10018601 | 0.83 | TNF (0.71) | TNFADORA2BUSP2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0956855-B1 | Immunosuppressive effects of 8 substituted xanthine derivatives | LEUVEN K U RES & DEV (BE) | 2003-03-12 | — | — | EP | claimed |
| EP-0956855-A1 | Immunosuppressive effects of 8-substituted xanthine derivatives | K.U. Leuven Research & Development (BE) | 1999-11-17 | — | — | EP | claimed |
| US-7253176-B1 | Immunosuppressive effects of 8-substituted xanthine derivatives | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2007-08-07 | — | — | US | disclosed |