Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 6/20 | 0.76 |
| ▸ | PDE4A | P27815 | 6/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384593 | 0.86 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL316911 | 0.82 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8861573 | 0.80 | TNF (0.82) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381243 | 0.77 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381262 | 0.76 | PDE4A (0.91) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5424162 | 0.75 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381251 | 0.75 | PDE4A (0.89) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17682312 | 0.74 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL315740 | 0.74 | ADORA2B (0.82) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21381247 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986561-B1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2005-07-27 | — | — | EP | disclosed |
| US-6562819-B2 | Antiinflammatory agents; antiproliferative agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-05-13 | — | — | US | disclosed |
| US-20020165202-A1 | Compounds for inhibition of ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-11-07 | — | — | US | disclosed |
| US-6323201-B1 | ANTIINFLAMMATORY AGENTS, ANTIPROLIFERATION AGENTS AND ENZYME INHIBITORS OF PHOSPHODIESTERASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165202-A1 | Compounds for inhibition of ceramide-mediated signal transduction | SMPD1, CERT1, SMPD3 | TNF 13/4885PDE4A 37/4885PDE4B 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.