Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383808 | 0.89 | GAA (0.50) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL7658063 | 0.88 | MAPT (0.49) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL7662303 | 0.86 | LOXL2 (0.45) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL6387042 | 0.86 | HSP90AA1 (0.51) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL28190926 | 0.86 | NR3C2 (0.42) | ALOX15HSD17B10MAPTKDM4ETP53 | |
| SCHEMBL7240826 | 0.85 | FFAR4 (0.45) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL7241172 | 0.85 | CCR6 (0.53) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL7570946 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HPGDALOX15HSD17B10FFAR4 | |
| SCHEMBL7240077 | 0.84 | CCR6 (0.46) | GAAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL7562440 | 0.84 | NPC1 (0.50) | ALOX15HSD17B10MAPTKDM4EFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209217-A1 | 3-Mercaptopyrrolidines as farnesyl protein transferase inhibitors | BOYLE FRANCIS T | 2005-09-22 | — | — | US | disclosed |
| US-6946468-B1 | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors | ZENECA LIMITED (GB) | 2005-09-20 | — | — | US | disclosed |
| US-6410539-B1 | ANTICARCINOGENIC AGENTS | ASTRAZENCA UK LIMITED (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| EP-1025089-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |
| EP-0923545-A1 | 3-MERCAPTOPYRROLIDINES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-06-23 | — | — | EP | disclosed |
| WO-1999020612-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |
| WO-1998007692-A1 | 3-MERCAPTOPYRROLIDINES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1998-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209217-A1 | 3-Mercaptopyrrolidines as farnesyl protein transferase inhibitors | FNTB, FNTA, KRAS | GAA 4063/4885ALDH1A1 1024/4885HPGD 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.