Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6385244 | 1.00 | MEN1 (0.42) | MEN1KMT2AL3MBTL1HPGDCHRM2 | |
| SCHEMBL6387798 | 0.83 | MAPK14 (0.43) | MEN1KMT2APTAFRMAPK14SMN1; SMN2 | |
| SCHEMBL6387801 | 0.83 | MAPK14 (0.43) | MEN1KMT2APTAFRMAPK14SMN1; SMN2 | |
| SCHEMBL7945985 | 0.82 | KMT2A (0.61) | MEN1KMT2AL3MBTL1HPGDCES1 | |
| SCHEMBL1864779 | 0.81 | CHRM2 (0.45) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL6387841 | 0.76 | CYP19A1 (0.40) | MEN1KMT2AADRA1AMAPK14CYP19A1 | |
| SCHEMBL6387839 | 0.76 | CYP19A1 (0.40) | MEN1KMT2AADRA1AMAPK14CYP19A1 | |
| SCHEMBL6385968 | 0.75 | KMT2A (0.44) | MEN1KMT2AL3MBTL1HPGDMIF | |
| SCHEMBL6385964 | 0.75 | KMT2A (0.44) | MEN1KMT2AL3MBTL1HPGDMIF | |
| SCHEMBL11838507 | 0.75 | HPGD (0.62) | MEN1KMT2AL3MBTL1HPGDCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | OPRK1, RECQL, OPRM1 | MEN1 2534/4885KMT2A 1888/4885L3MBTL1 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.