Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 12/20 | 0.43 |
| ▸ | DRD3 | P35462 | 10/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 9/20 | 0.40 |
| ▸ | DRD5 | P21918 | 7/20 | 0.40 |
| ▸ | DRD4 | P21917 | 6/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975342 | 0.74 | OPRK1 (0.48) | OPRK1DRD2DRD3CYP19A1DRD1 | |
| SCHEMBL8676741 | 0.73 | OPRK1 (0.53) | OPRK1DRD2DRD3CYP19A1DRD1 | |
| SCHEMBL18983710 | 0.71 | OPRK1 (0.50) | OPRK1DRD2DRD3CYP19A1DRD1 | |
| Tolnapersine SCHEMBL2109217 | 0.70 | SLC18A3 (0.48) | OPRK1DRD2DRD3DRD1DRD5 | |
| Bromide SCHEMBL9341124 | 0.70 | OPRK1 (0.49) | OPRK1DRD2DRD3CYP19A1DRD1 | |
| SCHEMBL18983559 | 0.70 | OPRK1 (0.49) | OPRK1DRD2DRD3CYP19A1DRD4 | |
| SCHEMBL27691473 | 0.69 | DRD2 (0.43) | OPRK1DRD2DRD3CYP19A1DRD1 | |
| SCHEMBL29683543 | 0.69 | OPRK1 (0.56) | OPRK1DRD2DRD3CYP19A1DRD4 | |
| SCHEMBL21780916 | 0.69 | OPRK1 (0.56) | OPRK1DRD2DRD3CYP19A1DRD4 | |
| SCHEMBL4362691 | 0.69 | OPRK1 (0.56) | OPRK1DRD2DRD3CYP19A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569897-A1 | SUBSTITUTED TETRALINS AND INDANES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-09-07 | — | — | EP | disclosed |
| EP-1554240-A1 | SUBSTITUTED TETRALINS AND INDANES AND THEIR USE | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004037779-A1 | SUBSTITUTED TETRALINS AND INDANES AND THEIR USE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-05-06 | — | — | WO | disclosed |
| WO-2004037778-A1 | SUBSTITUTED TETRALINS AND INDANES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-05-06 | — | — | WO | disclosed |